منابع مشابه
Aberrant Lipid Metabolism Promotes Prostate Cancer: Role in Cell Survival under Hypoxia and Extracellular Vesicles Biogenesis
Prostate cancer (PCa) is the leading malignancy among men in United States. Recent studies have focused on the identification of novel metabolic characteristics of PCa, aimed at devising better preventive and therapeutic approaches. PCa cells have revealed unique metabolic features such as higher expression of several enzymes associated with de novo lipogenesis, fatty acid up-take and β-oxidati...
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The stromal vasculature in tumors is a vital conduit of nutrients and oxygen for cancer cells. To date, the vast majority of studies have focused on unraveling the genetic basis of vessel sprouting (also termed angiogenesis). In contrast to the widely studied changes in cancer cell metabolism, insight in the metabolic regulation of angiogenesis is only just emerging. These studies show that met...
متن کاملReinventing cancer cell metabolism.
In today’s media world, when journal publications seem at times to be outdated by the time they appear in print, oncologists are fascinated to find that experiments reported some 80 years ago could be the object of surprising new discoveries. And yet, that is precisely the setting for the CCR Focus published in this issue of Clinical Cancer Research. In 1931, Otto Warburg (top photo) was awarde...
متن کاملHypoxia and Acidosis Independently Regulate Cell Immortality in Cancer Cell
Hypoxia and acidosis are hallmarks of tumors as well as critical determinants of response to cancer treatments. The development of tumor hypoxia has been shown to be a critical step in tumorigenesis and cancer cell metastasis. Low tumor pO2 has been correlated with poor patient survival and metastasis in several types of cancer. Specifically, cyclical hypoxia was found to be associated with sig...
متن کاملHypoxia. 2. Hypoxia regulates cellular metabolism.
Adaptation to lowering oxygen levels (hypoxia) requires coordinated downregulation of metabolic demand and supply to prevent a mismatch in ATP utilization and production that might culminate in a bioenergetic collapse. Hypoxia diminishes ATP utilization by downregulating protein translation and the activity of the Na-K-ATPase. Hypoxia diminishes ATP production in part by lowering the activity o...
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ژورنال
عنوان ژورنال: Acta Biochimica et Biophysica Sinica
سال: 2014
ISSN: 1672-9145,1745-7270
DOI: 10.1093/abbs/gmt148